Formulation and Evaluation of Floating Matrix Tablets of Sacubitril and Valsartan

Formulation and Evaluation of Sustained Release Matrix Tablets of Glipizide

      The purpose of this study was to develop a new monolithic matrix tablet to completely deliver glipizide in a zero order manner over a sustained period. Two approaches were examined using drug in a formulation that contain polymer like hydroxylpropyl methyl-cellulose K 100 (HPMCK) and Eudragit L 100. The granules were prepared by wet granulation method and thereby formulated as F-1, F-2. F...

Formulation and Evaluation of Bilayer Floating Matrix Tablets For Captopril

The importance of the present investigation was to formulate a bilayer-floating tablet (BFT) for captopril using direct compression technology. The release layer contained captopril and various polymers such as HPMC-K15M, PVP-K30 and Carbopol 934p, alone or in combination with the drug. HPMC, K-grade and effervescent mixture of citric acid and sodium bicarbonate formed the floating layer. The f...

Floating Matrix Tablets of Domperidone Formulation and Optimization Using Simplex Lattice Design

The purpose of this research was to prepare a floating matrix tablet containing domperidone as a model drug. Polyethylene oxide (PEO) and hydroxypropyl methylcellulose (HPMC) were evaluated for matrix-forming properties. A simplex lattice design was applied to systemically optimize the drug release profile. The amounts of PEO WSR 303, HPMC K15M and sodium bicarbonate were selected as independen...

Floating Matrix Tablets of Domperidone Formulation and Optimization Using Simplex Lattice Design

The purpose of this research was to prepare a floating matrix tablet containing domperidone as a model drug. Polyethylene oxide (PEO) and hydroxypropyl methylcellulose (HPMC) were evaluated for matrix-forming properties. A simplex lattice design was applied to systemically optimize the drug release profile. The amounts of PEO WSR 303, HPMC K15M and sodium bicarbonate were selected as independen...

formulation and evaluation of captopril floating matrix tablets based on gas formation